Ace Therapeutics has extensive expertise in the development of psychiatric cell models. We provide customized services for stem cells and neurons for psychiatric research, facilitating our clients' research and providing high-quality data.

Introduction of Cellular Model Development for Psychiatric Disorders

Mental illness is associated with significant economic, social, and personal burdens. Challenges such as disease heterogeneity, incomplete characterization of available drug targets, and limited understanding of complex pathogenesis have impacted the development of new therapies. Recent advances in genetics, molecular biology, and stem cell biology have accelerated our understanding of neuropsychiatric disorders such as autism spectrum disorder (ASD), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). Cell-based models can better represent and reveal the complexity of the pathophysiology of neuropsychiatric disorders.

Fig. 1 Brain correlates of in vitro iPSC cell phenotypes. (Falk A, et al., 2016)

Cellular Model Development Services for Psychiatric Disorders

The mission of Ace Therapeutics is to provide cellular models from high-quality sources for psychiatric pathology and drug discovery. We strongly believe that the use of effective cellular models increases the clinical relevance of neuroscience research programs. With our cellular models, you can study and model clinically important psychiatric disorders in relevant genetic and cellular environments. Our proven technology platform allows for the mass production of high-quality neurons to meet the greatest project needs.

The cell model development services we offer include, but are not limited to

• Cellular Model Development for Schizophrenia

We offer SH-SY5Y neuroblastoma cell models, iPSC-Derived Neural Cell Models, and glial cell models (including oligodendrocytes, astrocytes, and microglia) for schizophrenia research.

• Cellular Model Development for Depression

We offer primary neuronal cell models (cortical or hippocampal neurons), neuronal cell lines (rat clonal pheochromocytoma PC12, human neuroblastoma SH-SY5Y, mouse hippocampal HT-22), primary glial cell cultures (astrocytes, microglia) and glial cell lines (murine glioma C6, microglial BV2) models.

• Cellular Model Development for Bipolar Disorder

We provide lymphoblastoid cell lines, fibroblast olfactory neuronal epithelium (ONE) and neuronal cell models reprogrammed from IPSC for pathophysiological studies of BD and for drug development against bipolar disorder. We generate new insights into the mechanisms underlying the onset, progression, and eventual treatment of BD by generalizing and monitoring health and disease networks in culture dishes.

Integrated Supporting Services

• Process development
• Availability
• Cell banking
• Sequence analysis
• Long-term productivity and genetic stability studies
• Analytical services

Why Choose Us?

• Advanced cell line development platform
• Open access technology with flexible terms
• Robust cell lines with high protein productivity and excellent stability

Ace Therapeutics is committed to providing quality data and comprehensive services for your drug development, and we are happy to use our extensive experience and advanced platform to provide the best possible service to meet our clients' every need. If you are interested in this service please make an inquiry to learn how we can support you in your project.

Reference

1. Falk A, et al. Modeling psychiatric disorders: from genomic findings to cellular phenotypes [published correction appears in Mol Psychiatry. 2016 Sep;21(9):1321]. Mol Psychiatry. 2016, 21(9):1167-1179.