Treatment of Depression
Depression can be treated with a variety of therapies, which include a combination of psychotherapy and medication. Psychotherapy assists patients in overcoming negative emotions and resuming daily life. Medication regulates the patient's brain circuits of mood, thinking, and behavior to improve symptoms. However, antidepressants take weeks or even months to have an effect, so it is important to stay on them. As with any chronic illness, early diagnosis and treatment can reduce the intensity and duration of depressive symptoms, while reducing the risk of relapse.
Current Status of Antidepressant Research
Currently, the pathogenesis of depression remains to be elucidated. Studies suggest that depression may be due to deficiencies in the function of central monoamine neurotransmitters (5-HT and NA), resulting in low overall body mood activity. Accordingly, the mechanism of action of current antidepressant drugs mainly targets the regulation of neurotransmitter levels. Currently approved antidepressants are mainly small molecule drugs, including a small number of herbal medicines. At the same time, a large number of new therapies or large molecule drugs are in clinical research, such as stem cell therapy, microecology, monoclonal antibodies, etc. The current status of antidepressant drug development is as follows
- Traditional Chinese Medicine
- Stem cell therapy
- Microecologics
- Radiopharmaceuticals for diagnosis
- Toxin
- Tumor necrosis factor
- Synthetic peptide
- Monoclonal antibody
Major Targets for Antidepressant Drug Development
- SERT
- NET
- MATs
- D2 receptor
- GABAA receptor
- HT1A receptor
- 5-HT2A receptor
- DAT
- MAO
How Can We Help?
Ace Therapeutics has extensive experience in psychopathology research and antipsychotic drug development. We are committed to supporting scientists in making groundbreaking scientific discoveries and developing new applications to accelerate drug discovery and the scientific diagnosis and treatment of antipsychotic disorders. We offer many research services including but not limited to
- Drug mechanism of action studies: We can assist you in studying the mechanism of action of antidepressants to better understand how these drugs work at the chemical and neurobiological levels.
- Drug safety and efficacy studies: We can help you evaluate the safety and efficacy of antidepressants and explore ways to optimize the therapeutic effects of these drugs.
- Development of new antidepressants: We help you develop new antidepressants that may be helpful for patients who do not adapt to existing medications or for those who have lost the effectiveness of their medications.
- Research on personalized treatment with antidepressants: Because of differences in the symptoms and presentation of depression, personalized treatment has become a hot topic of research in recent years. We can help you explore how to develop the best treatment options based on a patient's specific symptoms and presentation.
Related Services
Ace Therapeutics, a preclinical R&D outsourcing service provider, is committed to providing a full range of preclinical research services to global pharmaceutical companies, research institutions, and investigators to advance the process of antipsychotic drug research. If you are interested in our services, please feel free to make an inquiry.
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