Electrophysiological Analysis in Psychiatry
Ace Therapeutics is committed to providing professional electrophysiological analysis and custom services to accelerate your psychiatric disease research process and psychiatric disease therapy development. Our team of experienced scientists, researchers and technicians provides fast turnaround, high quality services at competitive prices to our clients worldwide.
Introduction of Electrophysiological Analysis in Psychiatry
Cognitive impairment is considered to be an essential feature of schizophrenia. Patients with this disorder have impairments in multiple cognitive domains, such as executive functioning, certain types of memory, attention, fluency, and information processing/speed. Electrophysiological markers, including electroencephalography (EEG), particularly event-related potentials, have contributed to psychiatric research and clinical practice. There is evidence that electrophysiological measures are objective markers of neuropsychological performance. Electrophysiological responses often precede behavior-based cognitive performance and also help predict treatment outcomes for cognitive disorders.
Fig. 1 Microelectrodes are essential for neuroscience studies. (Xu T, et al., 2022)
Electrophysiological Analysis Services
Ace Therapeutics offers a comprehensive range of in vitro electrophysiological analyses to monitor interneuronal communication and study the effects of physiological or pharmacological stimuli associated with psychiatric disorders. Our in vitro electrophysiological analyses include two-electrode voltage clamp (TEVC) Services, Patch-Clamp Services, and Microelectrode Arrays (MEA) Services, and we can use one or a combination of several methods to help researchers Evaluate the GABAergic activity of compounds (many psychotherapeutic drugs, including clozapine, have multiple pharmacological effects and act on GABAA receptors) and elucidate the role of neurotransmitter receptors in various neuropsychiatric disorders.
TEVC Services
Measurement of ion channel currents in a range of cells including neurons and in specific cellular regions including presynaptic terminals and dendritic spines
Patch Clamp Services
Separation of signal changes originating from synaptic and intrinsic excitability changes
MEA Services
Recording spike activity and field potential propagation in different regions with high spatial and temporal resolution
Ace Therapeutics provides in vivo electrophysiology services for neurobiological studies of antipsychotic drugs. These include EGG recording and analysis services, electromyography (EMG) recording and analysis services, electrocardiogram (ECG) recording and analysis services, deep brain stimulation (DBS) services, and long-term potentiation (LTP) recording services. We help you study the relationship between antipsychotic medications and mood dynamics and mood-related brain circuits through in vivo electrophysiological signals. It is critical to elucidate important properties of the nervous system associated with mental illness, to explore the neural mechanisms behind behavioral effects, and to evaluate new therapies for mental illness.
EEG Services
Recording of cortical activity (electrocorticography), resulting in high quality data
EMG Services
Automatically and accurately track minute movements to accurately characterize psychiatric phenotypes
ECG Services
Recording of electrocardiograms in conscious mice, rats and guinea pigs
DBS Services
Performing DBS unilaterally or bilaterally in rodents to evaluate new psychiatric indications and novel techniques
LTP Services
Providing a special macroscopic view of natural neuronal networks with fast turnaround capabilities
What Can We Help You Achieve in Psychiatry?
- Understanding brain network dynamics
- Studying the Cellular Molecular Basis of Schizophrenia
- Predicting clinical response to psychotropic drug treatment
- Developing personalized treatment response biomarkers for antidepressants
- Monitoring the efficacy and toxicity of psychotropic drugs at the CNS leveloping personalized treatment response biomarkers for antidepressantevel
- Predicting idiopathic rapid eye movement sleep behavior disorder
- Assessing the relationship between psycho-emotional state and muscle tone
Our Advantages
- Free experimental protocol evaluation
- Strict quality control standards
- Competitive pricing and fast turnaround time
Ace Therapeutics is dedicated to supporting biomarker and therapy development for psychiatric disorders through in vitro
electrophysiological analysis. We aim to help you achieve faster data analysis and accurate measurements and to advance your understanding of the pathogenesis of psychiatric disorders. make an inquiry to discuss how our services can bring new key insights to your project or to request a quote.
Reference
- Xu T, et al. Support-Free PEDOT: PSS Fibers as Multifunctional Microelectrodes for In Vivo Neural Recording and Modulation. Angew Chem Int Ed Engl. 2022, 61(16):e202115074.
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