Ace Therapeutics' MetaQuant Dialysis is a novel dialysis technique that can be used for multiple aspects of the antipsychotic drug development process, including drug metabolism, potency, toxicity, structure, and activity studies, helping to accelerate the drug development process and selecting the optimal drug dose and dosing regimen.

Introduction of MetaQuant Microdialysis in Antipsychotic Drug Development

The only method to quantify free extracellular drug levels in the brain of living animals is microdialysis. Intracerebral microdialysis offers many advantages in measuring endogenous and exogenous compounds in localized brain regions of anesthetized or freely moving animals. The MetaQuant probe differs from conventional probes in that it has two inflow lines. One is an ultra-slow flow that perfuses the dialysis tip in much the same way as a conventional microdialysis probe. The other is a carrier flow, which reaches only the body of the probe. As a result, the flow through the dialysis tip is at an ultra-slow flow rate and achieves a recovery rate close to 100%. Free brain concentration is determined directly, quickly, and reliably using MetaQuant technology.

MetaQuant Microdialysis Services

Ace Therapeutics is committed to providing true quantitative dialysis through MetaQuant probes, thus helping you save time and money in antipsychotic drug development. Typically, the free drug concentration in a tissue is calculated by measuring the total drug concentration and then subtracting the bound drug from the in vitro protein binding calculation. Our proprietary MetaQuant probe accurately measures the actual free drug concentration, as well as the inferred concentration based on standard calculations. Our MetaQuant probes have a special structure and this low flow rate is supported by a higher carrier flow rate at the outlet of the semi-permeable portion of the probe for faster removal of dialysate, allowing for more frequent and larger volume sampling, contributing to temporal resolution and chemical analysis of samples.

Advantages of Our Technology

• No more anomalies between in vitro and in vivo data
• Fewer animals required for testing
• Fast turnaround, no need for extensive validation
• Ability to track the same animal over time and combine it with other technologies

Our MetaQuant Dialysis Technology in Antipsychotics Discovery

• Drug metabolism study: We can monitor the metabolites of drugs in animals by MetaQuant dialysis method, which helps you understand the metabolic pathways and metabolites of drugs, so that you can choose the best drug dose and dosing regimen.
• Drug efficacy studies: Our MetaQuant dialysis method allows you to monitor the effects of drugs in animals, including the time course of action, dose-response relationship, and duration of effect, in order to evaluate the efficacy of drugs.
• Drug toxicity studies: Our MetaQuant dialysis method can help you assess drug toxicity and monitor the release of drug metabolites and toxic metabolites.
• Drug structure and activity studies: Our MetaQuant dialysis method can help you understand the relationship between drug structure and activity, which can guide the design and improvement of drugs.

Ace Therapeutics is dedicated to monitoring a range of neurotransmitters and biomarkers in the blood through the MetaQuant dialysis method. Our MetaQuant method can be customized with probes to perform metabolite analysis and identification. Most importantly, we can help you monitor free drug concentrations in different tissues in the body and in different parts of the brain, which can accelerate the development of your available antipsychotic drugs.