Obsessive–compulsive Disorder Animal Models
Ace Therapeutics has been focusing on the development and optimization of animal models of psychiatric diseases for many years, and has established an excellent research platform for the development of antipsychotic drugs. We are committed to providing customized services for autism animal models for mental disease research, helping researchers to achieve their research goals smoothly.
Introduction of Obsessive–compulsive Disorder Animal Models
Obsessive-compulsive disorder (OCD) is a disabling common neuropsychiatric disorder of unknown etiology characterized by disturbing, persistent thoughts, images, or urges that are experienced as intrusive and meaningless and cause marked distress or anxiety (obsessions) and/or excessive repetition of behaviors or mental actions deliberately designed to neutralize such distress (compulsions). Over the past few decades, many attempts have been made to develop animal models of OCD that may help to unravel the genetic, neurochemical, and neuroanatomical basis of the disorder and aid in the development of new treatments methods and describe the mechanisms by which these treatments exert their beneficial effects.
Fig. 1 Simplified neuroanatomic models of corticostriatal circuitry within the human (top) and mouse (bottom) brain. (Monteiro P, et al., 2016)
Animal Modeling Services for OCD
Ace Therapeutics has developed a variety of animal models of OCD through genetic, pharmacologically induced, behavior-based manipulation, and neurodevelopmental approaches that can be used to study key insights about anxiety-like behaviors and abnormal repetitive and compulsive behaviors, including compulsive grooming, sustained responses during reverse learning, and sustained excessive movement could also be used to develop new therapeutic strategies for OCD and other related disorders.
Information on animal models of autism we provide:
Table 1 Animal models of OCD.
| Model |
OCD-relevant characteristics |
| Genetic |
| Hoxb8-KO mouse |
Excessive self-grooming |
| Sapap3-KO mouse |
Excessive self-grooming, increased anxiety, impaired reversal learning, impaired habit formation |
| Slitrk5-knockout mouse |
Excessive self-grooming, increased anxiety |
| Spred2-KO mouse |
Excessive self-grooming |
| Slc1a1 ST mouse |
Decreased AMPH response |
| Slc1a1-OE mouse |
Increased AMPH response |
| DAT knockdown mouse |
Stereotyped syntactic grooming chains |
| 5-HT2C KO mouse |
Methodical screen chewing, repetitive head dipping |
| Circuit manipulation |
| D1-cholera toxin (CT) mice |
Repetitive selection of actions |
| OFC-VMS optogenetic stimulation |
Progressive increase in grooming |
| LOFC-CS optogenetic stim in Sapap3-KOs |
Reduced self-grooming |
| BLA-DLS optogenetic stimulation |
Progressive increase in self- grooming & anxiety-like behavior |
| ChAT interneu- ron ablation (DLS) |
Increased stress-induced grooming, AMPH-induced stereotypies |
| PV interneuron ablation (DS) |
Increased stress-induced grooming |
| Pharmacologic manipulation |
| Quinpirole |
Repetitive checking behavior |
| RU24969 |
Perseverative hyperlocomotion, PPI deficits |
| mCPP |
Increased directional persistence in T-maze rewarded alternation task |
Note: Our service list is constantly updated and improved. Please contact us via email for more latest information and related information.
Information to Be Confirmed
Delivery Standard
Ace Therapeutics offers a variety of animal models for studying the genetic, neurochemical and neuroanatomical basis of OCD. Please tell us your project requirements, we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to make an inquiry.
References
- Monteiro P, Feng G. Learning From Animal Models of Obsessive-Compulsive Disorder. Biol Psychiatry. 2016, 79(1):7-16.
- Chamberlain BL, Ahmar SE. Animal Models for OCD Research. Current Topics in Behavioral Neurosciences. 2021, 55–96.
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