Ace Therapeutics provides pharmacokinetic services for antipsychotics, including the study and analysis of the processes of absorption, distribution, metabolism, and excretion in the body to determine the optimal drug dose, mode of administration, and frequency of administration.

Introduction of Pharmacokinetics Analysis for Antipsychotics

Antipsychotics are a group of chemically distinct heterocyclic compounds that improve many of the symptoms of schizophrenia. The existence of an optimal therapeutic range for most antipsychotic drugs remains controversial. One of the main problems is the lack of well-designed studies, which is further complicated by the presence of a large number of pharmacologically active metabolites. Pharmacokinetic studies are the science of studying the absorption, distribution, metabolism, and excretion processes of drugs in the body. Pharmacokinetic studies of psychiatric drugs can help improve the outcome of patients with psychiatric disorders, reduce the risk of side effects and adverse reactions, and provide a scientific basis for individualized treatment.

Fig. 1 The principle of brain microdialysis. (Luc P, et al., 2013)

Pharmacokinetics Analysis Services

Ace Therapeutics can help design and customize the best pharmacokinetic study protocol to fit your antipsychotics discovery program. We can examine multiple parameters, including detailed information about the route, the concentration of administration, timing, etc., to ensure the success of your post-renewal study. In addition, we offer a range of analytical support including

• Conventional Microdialysis in Antipsychotic Drug Development

We can analyze a variety of neurotransmitters in the extracellular space of the rodent brain through conventional microdialysis. By combining microdialysis with sensitive bioanalytical techniques to provide the most comprehensive information, we help you understand the dynamics of molecular concentrations involved in intercellular communication and metabolism in awake, freely moving animals.

• MetaQuant Microdialysis in Antipsychotic Drug Development

We offer true quantitative dialysis through our MetaQuant probes, which can be used for multiple aspects of the antipsychotic drug development process, including drug metabolism, potency, toxicity, structure, and activity studies.

• Push-Pull Microdialysis in Antipsychotic Drug Development

We offer a push-pull microdialysis technique for the collection of macromolecules. We combine this technique with immunoassays for measuring dynamic changes in peptides, proteins, and other macromolecules such as α-synuclein, Tau, and cytokines.

• Multiple Probes and Combined Services in Antipsychotic Drug Development

We can customize assays by combining PK or PD microdialysis techniques or by combining microdialysis with other methods, such as behavioral or EEG measurements. We can perform real-time measurements of pharmacodynamic changes in neurotransmitters, modulators, and proteins through a multi-probe approach while collecting free drug concentrations to establish an accurate PK/PD relationship.

Ace Therapeutics' pharmacokinetic services can improve the therapeutic efficacy of antipsychotic drugs, mitigate the risk of adverse effects, and provide the scientific basis for individualized treatment. From standard screening to more complex studies, our experienced scientists can help design optimal strategies and customize protocols to fit any drug discovery program. If you are interested in this service, please make an inquiry to learn how we can support you in your project.

Reference

1. Luc P, et al. Animal Models and Methods to Study the Relationships Between Brain and Tissues in Metabolic Regulation. Academic Press. 2013, 569-593.