Ace Therapeutics offers comprehensive biomarker identification services that enable researchers to gain a fuller understanding of the molecular changes behind a specific disease or during a response to a specific treatment. Rely on our flexible approach, extensive experience, well-established and validated workflow, highly specialized bioinformatics team, an extensive collection of historical data, high quality and fast turnaround to support your preclinical drug development for psychiatric disorders.

Introduction of Psychiatric Predictive Biomaker Identification

The identification and use of predictive biomarker assays have become an integral part of the drug discovery and development process. Predictive biomarkers are used to identify individuals who are more likely to respond to exposure to specific medical products or environmental factors.

Fig. 1 Psychotropic medications: pharmacogenomic biomarkers in drug labeling. (Lozupone M, et al., 2019)

Biomarker Identification Services

Ace Therapeutics has extensive expertise in biomarker identification in the therapeutic area of psychiatric disorders. Our scientific experts and biomarker lab staff can help you develop translational design strategies to identify, develop assays and screen multiple biomarkers in parallel, so the most relevant biomarkers can be identified faster and give you early proof-of-concept. Our capabilities span the identification and validation of biomarkers and the the development of primary cell and disease tissue, pharmacodynamic and disease model quantitative assays, as well as development of markers for clinical efficacy and translational medicine.

Our Assay Technologies

• Multiparametric flow cytometry
• Immunohistochemistry, high-throughput imaging/analysis and pathology
• Cytokine and chemokine analysis based on single and multiplex ELISA
• Genomic analysis based on high-sensitivity PCR, real-time PCR and NGS technologies
• Bioinformatics to guide biomarker discovery and validation, statistical analysis and preclinical studies
• Rare cell analysis for detection and monitoring of CTCs, CAR-T cells, etc.
• Complete blood count

Example Readouts

• Proteomic markers
• Genomic markers
• Phosphoprotein markers
• Epigenetic markers

Advantages of Our Services

• Save time and money costs
• Robust and reliable results
• Strict quality control
• High throughput data analysis

Ace Therapeutics can assist in the identification of psychiatric disease-related biomarkers, while measuring and interpreting their variation in the test system, linking them to drug development programs. From analytical identification to full validation, our experts recommend fit-for-purpose validation that is fully adapted to the environment in which your biomarker will be used. We work with customers around the world to bring a wide range of biomarkers to market as drug development tools. Please feel free to make an inquiry to learn how our specialized laboratory services can advance your preclinical development program.

Reference

1. Lozupone M, et al. The Role of Biomarkers in Psychiatry. Adv Exp Med Biol. 2019, 1118:135-162.