Treatment of Schizophrenia
Schizophrenia is usually treated with a combination of individualized talk therapy and medications. Antipsychotics are often recommended as initial treatment for symptoms of acute schizophrenic episodes. These medications reduce the symptoms of schizophrenia, including hallucinations, delusions, and disorganized thinking, primarily by modulating neurotransmitter levels. Antipsychotics can usually reduce anxiety or feelings of aggression within hours of use, but it may take days or weeks to reduce other symptoms, such as hallucinations or delusions.
Current Status of Research on Anti-schizophrenia Drugs
Treatments for schizophrenia are divided into first-generation (mainly dopamine D2 receptor antagonists), second-generation (multi-target antagonists whose antagonism of 5-hydroxytryptamine 5-HT2A receptors is greater than that of dopamine D2 receptors), and third-generation antipsychotics, such as aripiprazole, brexpiprazole and carpoprazine as representatives.
Advantages of Different Anti-schizophrenia Drugs
| First-generation anti-schizophrenic drugs |
Second-generation anti-schizophrenic drugs |
Third-generation anti-schizophrenic drugs |
Effective control of schizophrenic symptoms.
Lower cost. |
Fewer extrapyramidal side effects.
Better therapeutic effect and duration of efficacy.
More manageable side effects.
More significant improvement in sleep and affective disorders. |
Less risk of metabolic syndrome (abdominal obesity, hypertension, hyperglycemia, hyperlipidemia)
More significant improvement in cognitive function and negative symptoms in patients. |
Disadvantages of Different Anti-schizophrenia Drugs
| First-generation anti-schizophrenic drugs |
Second-generation anti-schizophrenic drugs |
Third-generation anti-schizophrenic drugs |
Obvious extrapyramidal side effects, including muscle stiffness, tremor, stuttering, and eye rolling up.
Long-term use is prone to adverse reactions such as neoplastic pyramidal signs and progeny dyskinesia. |
Some drugs can still cause metabolic disorders and heavy weight gain.
Some drugs have adverse effects on cardiovascular function. |
Higher cost than first-generation drugs.
Less improvement in metabolic disorders than second-generation drugs. |
Major Targets for Anti-schizophrenia Drug Development
- Dopamine D2 receptors
- 5-hydroxytryptamine 2A receptor
- Neurotransmitter glutamate
- Neuropeptide Y (NPY)
- α1-Adrenergic receptors
How Can We Help?
Ace Therapeutics has deep experience in psychiatric research and antipsychotic drug development. We are committed to helping you develop new anti-schizophrenic drugs with improved efficacy and reduced side effects. We offer many research services including but not limited to
- New drug development: In cases where existing anti-schizophrenic drugs do not provide complete relief, we can help you develop new drugs that are more effective, provide faster relief of schizophrenic symptoms, and may reduce side effects.
- Discovering new targets: We can help you find new targets and develop new anti-schizophrenic drugs on those targets to improve the efficacy and safety of your drugs.
- Studying the side effects of drugs: Many anti-schizophrenic drugs are available, but long-term use can cause many side effects, such as diabetes, heart disease, and obesity. We can help you explore ways to mitigate or avoid the side effects of these medications.
- Drug combinations: We can help you study combinations of different kinds of anti-schizophrenic drugs to find the most effective combination regimen.
Related Services
With Ace Therapeutics' extensive experience in early-stage antipsychotic drug discovery, we have a deep understanding of psychiatric disorders. As a result, we can meet your requirements and provide reliable services. If you are interested in our services, please make an inquiry to learn how we can support you in your project.
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