Biomarker Measurement Services for Stroke

Differential markers in stroke pathological processes can indicate indicators of the pathological process of stroke and the pharmacological effects of drug treatment. Therefore, identifying differential markers in stroke pathological processes helps to accurately probe the mechanism of action of drug candidates in the organism and to facilitate the understanding of stroke pathological processes, which plays an important role in pharmacodynamic studies. Therefore, Ace Neuroscience provides comprehensive services to explore the differential expression of different biomarkers in stroke-related pharmacodynamic studies.

Biomarker Measurement Services for Stroke

High Throughput Screening of Differential Biomarkers

Ace Neuroscience performs high throughput screening of markers by different protein microarray and gene microarray techniques to screen for differential markers in terms of expression level, binding affinity, protein-nucleic acid interactions, and other aspects. After obtaining the differential markers, we validate them by ELISA, western blotting, two-dimensional gel electrophoresis, immunohistochemistry, and other assays to investigate their mechanism of action and function in stroke pathology.

Detection of Neuroprotection Biomarkers

Neuroprotection is an effective way to treat stroke. Neuroprotection can provide targeted protective effects for different pathological stages after stroke. A number of specific biomarkers for neuroprotection have been identified, such as human urokinase (HUK), which reduces infarct size and improves neurological deficits while increasing local vasodilation and neuroprotection. Ace Neuroscience provides comprehensive biotechnology services to screen for biomarkers of the neuroprotective process in stroke while exploring their specific mechanisms of action.

  • Quantitative detection and functional validation of genes by rt-PCR, northern blotting, fluorescence in situ hybridization, overexpression of target genes, knockout of target genes, reversion experiments, and other assays.
  • Protein quantification and localization by ELISA, western blotting, immunohistochemistry, immunofluorescence, and other assays to investigate the mechanism of action in neuroprotection.
  • Nucleic acid-protein interactions are explored by luciferase reporter systems, RNA pull-down, RIP-PCR, gel migration or electrophoretic mobility shift assays, and other assays.

Detection of Inflammation Biomarkers

Inflammation, especially neuroinflammation, is crucial in the stroke process. After stroke onset, neuroinflammation can induce secondary brain injury after stroke. Therefore, timely prevention and control of inflammation occurring after stroke can effectively mitigate the damage of stroke. Many biomarkers associated with inflammation during the stroke, such as CD11b and TNF-α, have been identified and are involved in a variety of pathological processes during stroke episodes, thus not only exploring the pathological processes of stroke but also providing targeted therapeutic development for the biomarkers. Ace Neuroscience offers comprehensive services to facilitate the study of inflammation-related biomarkers in the stroke process.

Biomarker Measurement Services for Stroke

In addition, Ace Neuroscience offers testing services for oxidative stress, cell death, blood brain barrier, and other biomarkers of pathological processes during the stroke. If you would like to learn more about our services, please feel free to contact us.

Reference
  1. Paul, S.Candelario-Jalil, E. Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies. Exp Neurol, 2021. 335: p. 113518.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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