Drug Screening Platform Services

A well-developed drug screening platform can accelerate the process of drug discovery and reduce the cost of drug development, which is essential for drug development. Ace Neuroscience has expertise in the field of stroke research, state-of-the-art technology, and the most complete equipment. We offer high throughput screening, high content imaging technology platforms, as well as target-based, fragment-based drug screening platforms, DNA-encoded library technology, and computer-aided drug design technologies. Our comprehensive services are designed to facilitate the smooth conduct of your research.

Drug Screening Platform Services

High Throughput Screening for Stroke Drug Development

High-throughput screening (HTS) is an effective way to rapidly identify potentially active compounds and is widely used in drug discovery, Ace Neuroscience has established a comprehensive high throughput screening platform for stroke drug development. Our scientists will develop a scientific screening protocol based on your experimental protocol and then process and analyze the data to obtain the compounds that meet your needs.

  • Based on our ultra-large small molecule library, we can efficiently screen all aspects of stroke research to find drug candidates.
  • With expertise and flawless service, we will continually optimize our screening programs to meet your needs and maximize your expectations.
  • Our high throughput screening platform fully automates the entire screening process, while providing high sensitivity and selectivity to ensure more stable and reproducible screening with less sample volume.
  • We continuously optimize the corresponding database and technical systems to increase the hit rate of drug candidates.

High Content Imaging for Stroke Drug Development

High content imaging is now widely used in various research phases of drug development, including target discovery, target validation, primary screening of activity, metabolism, and toxicology. High content imaging combines the techniques of automated imaging and data analysis to enable quantitative analysis of cellular events based on various biochemical / physical characteristics of sample cells.

Exploration of the Relationship Between Drug And Target Interactions

High content imaging allows the visualization and quantification of sample cells to detect the effects of drug candidates on cellular morphology and function, including changes in cell shape, morphology, and target distribution, to increase understanding of the drug candidates' effects.

Toxicity Studies

Toxicity studies of drug candidates are performed by measuring cell morphology, cell viability, and other indicators to assess the toxic effects of drug candidates on cells.

Screening of Drug Candidates

Obtain the differential effects of drug candidates on cells in the early stages of drug development, including toxicology, metabolism, and mechanism of action, accelerates the drug screening process.

Other Drug Screening Platforms

In addition to the above technology platforms, we also offer target-based drug development platforms, fragment-based drug development platforms, virtual screening platforms for drugs, gene coding library technology platforms, and computer-aided drug design technology platforms. We offer a comprehensive range of services just to facilitate the smooth progress of your research.

Target- Based Drug Screening Platform

We have developed target-based drug screening technologies for different targets, such as enzyme targets, nuclear receptor targets, ion channel targets, and GPCR receptor targets. We quantify the effect of drug candidates on targets by fluorescence, absorbance light, chemiluminescence, enzyme-linked reaction, and NMR.

Fragment-Based Drug Screening Platform

We perform high-quality fragment screening by various orthogonal screening methods to obtain fragments that have the ability to bind to targets and are potentially active. To improve the bioactivity and other properties of the fragments such as target specificity, bioavailability, and ADME, we provide services including fragment growth, fragment jumping, and fragment linkage.

DNA-Encoded Library Technology Platform

DNA-encoded library is screened by affinity with the target protein to obtain a collection of compounds that can bind to the protein, and compounds that cannot bind effectively to the target protein are removed by elution, which enables rapid and efficient construction and screening of libraries of hundreds of millions of molecules.

Computer-Aided Drug Design

Computer-aided drug design can perform molecular structure analysis, target structure construction, drug active conformation, pharmacodynamic group identification, target-drug action model simulation, and three-dimensional quantitative drug conformational relationship analysis, which can be widely applied to the process of lead compound discovery and optimization.

At the same time, we can tailor our research services exclusively to your research needs. If you would like to learn more about our services, please feel free to contact us.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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