Exploration of the Role of Astrocytes in Stroke

After the onset of ischemic stroke, astrocytes undergo dramatic morphological changes, which are often referred to as reactive astrogliosis after ischemic injury. Astrocytes are involved in regulating the pathological process of stroke by regulating activities such as glial scar formation, astrocyte gap junctions, and maintenance of the blood-brain barrier. However, the exact mechanism of action is not clear. Therefore, exploring the role of astrocytes in stroke is essential to uncover the pathological process of stroke. Ace Therapeutics provides a comprehensive service to explore the different roles and functions of astrocytes in the pathological process of stroke.

Exploration of The Deleterious Effects of Astrocytes on Stroke

Astrocytes are involved in mediating a variety of central system pathological processes. Among them, reactive astrocytes promote neuroinflammation and brain edema, and glial scarring impedes neurological recovery. However, more details need to be uncovered by additional studies.Ace Therapeutics offers a range of services to explore the deleterious effects of astrocytes on stroke.

• For reactive astrocytes, we provide assays such as Diolistic labeling, dye filling, cytoplasmic labeling of fluorescent proteins, membrane labeling of fluorescent proteins, and GFAP antibody labeling of cytoskeleton expression to detect astrocytes changes.
• For astrocyte-mediated inflammatory responses, we provide detection of characteristic biomarkers such as NF-kB, lactose ceramide, S1PR1, and pro-inflammatory mediators.

Exploration of The Beneficial Effects of Astrocytes on Stroke

As research on astrocytes progresses, there is a growing understanding of the beneficial effects of astrocytes on the stroke process. For example, glial scarring can effectively isolate the site of injury from healthy tissue and limit the spread of tissue damage, reactive astrocytes can secrete a variety of neurotrophic factors to protect neurons. Ace Therapeutics provides a comprehensive scientific research service to explore the beneficial effects of various astrocytes on stroke.

• We explore differential genes in experimental models of astrocyte functional abnormalities by genome sequencing.
• We provide models of excitotoxicity, oxidative stress, and mitochondrial dysfunction to explore the role of astrocytes in these pathological processes.
• We offer assays for various substances related to these processes, such as glutamate, glutathione, exosomes, erythropoietin, and glial-derived neurotrophic factors.
• We assess the effect of astrocytes on BBB by detecting blood-brain barrier integrity and permeability.
• We offer experimental models of stroke combined with assays to explore the role of astrocytes in stroke, including post-stroke infarct volume changes, astrocyte activity, and biomarker assays.

In addition, Ace Therapeutics provides a one-stop scientific service to explore the role of astrocytes in stroke in a scientific and accurate manner. If you would like to learn more about our services, please feel free to contact us.

1. Kesavardhana, S., et al., Caspases in cell death, inflammation, and pyroptosis. Annu Rev Immunol, 2020. 38: p. 567-595.
2. Gou, X., et al., Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies. J Physiol Biochem, 2021. 77(4): p. 511-529.