Exploration of the Role of Caveolin-1 in Stroke

Ace Therapeutics aims to contribute to the investigation of stroke pathogenesis.

Although Caveolin-1 (Cav-1) has been reported to exert protective effects on the brain during a stroke by affecting the blood brain barrier, neuroinflammation, oxidative stress, and other physiological and pathological processes, the exact mechanism of action is not known. We offer comprehensive services to explore the role of Cav-1 in stroke pathology. Our scientists have decades of experience in the field of stroke research and keep abreast of advances in stroke research to provide the best possible knowledge base to assist you in your research.

Exploration of the Role of Cav-1 in Ischemic Stroke

During ischemic stroke, Cav-1 regulates the process of stroke attack by modulating many processes such as blood brain barrier (BBB) permeability, neuroinflammation, angiogenesis, neurogenesis, and cell apoptosis. Ace Therapeutics provides comprehensive services to explore the role of Cav-1 in the pathology of ischemic stroke.

• Ischemic stroke models are an important tool to explore the role of Cav-1 in ischemic stroke. We have a well-established protocol for establishing ischemic stroke models to ensure the scientific validity and reproducibility of the models.
• For the effect of Cav-1 on BBB, we have extensive experience in BBB barrier models to provide you with a suitable BBB model. Further studies have demonstrated that Cav-1 mainly acts through trans- and paracellular pathways, therefore, for the related mechanism of action, we provide a comprehensive exploration service.
• For the effects of Cav-1 on neuronal growth and neuroplasticity, we provide screening and testing services for related pathways, including PI3k/Akt signaling pathway, MAPK/ERK signaling pathway, NF-κB signaling pathway, Sonic hedgehog signaling pathway, cAMP signaling pathways, and other signaling pathways.
• For the effect of Cav-1 on cell apoptosis, we provide cell activity assay service, cell apoptosis pathway related gene and protein assay services and other related services.

Exploration of the Role of Cav-1 in Hemorrhagic Stroke

Studies have shown that Cav-1 can be involved in stroke pathology through modulation of oxidative stress, cellular activity, brain damage, and neurological function, but the exact mechanism of action is not yet known. Ace Therapeutics provides comprehensive services to explore the role of Cav-1 in hemorrhagic stroke.

• For Cav-1 to regulate the process of hemorrhagic stroke by regulating oxidative stress, we provide assays for oxidative stress processes, mainly HO-1 and reactive oxygen species.
• For Cav-1 to regulate the process of hemorrhagic stroke by regulating neuronal activity, we provide cell activity assays for a variety of brain cells, including neurons, and we can identify the type of cell death to further elucidate the stroke pathology.
• For the alleviating effect of Cav-1 on stroke brain damage, we provide different hemorrhagic stroke models. We have also established comprehensive protocols for evaluating post-stroke brain damage to scientifically and comprehensively measure the extent of post-stroke brain damage.
• We have established well-established behavioral testing protocols. By performing behavioral tests on post-stroke animals, you can provide stronger evidence for your research.

In addition, Ace Therapeutics provides a one-stop scientific service to explore the role of Cav-1 in stroke in a scientific and accurate manner. If you would like to learn more about our services, please feel free to contact us.

1. Chang, C. F., et al., Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage. Am J Pathol, 2011. 178(4): p. 1749-1761.