Exploration of the Role of DAPK1 in Stroke

Death-associated protein kinase 1 (DAPK1) plays an important role in various apoptotic pathways of the body. Recent studies have the requirement of DAPK1 catalytic activity for cellular function in models of neurological diseases including stroke, in addition, the catalytic activity of DAPK1 is significantly increased in injured neurons. These results confirm DAPK1 as a potential therapeutic target for these diseases. Given the important role of DAPK1 catalytic activity in cellular function, Ace Therapeutics provides comprehensive services to explore the specific mechanism of DAPK1 in the pathological process of stroke.

Exploration of the Role of DAPK1 in Stroke

Given the role of DAPK1 in the process of ischemic stroke, Ace Therapeutics provides quality services to explore the role DAPK1 plays in stroke pathology.

• We have established different stroke models in vitro and in vivo to explore the role of DAPK1 in stroke pathology.
• We have established in vitro and in vivo models of abnormal DAPK1 expression by drug administration and genetic manipulation.
• We delve into the specific mechanism of action of DAPK1 with different targets by means of protein interactions.
• For animal models, we provide pathology services to detect brain damage in animals after a stroke.
• For animal models, we provide comprehensive behavioral assessment services to measure behavioral, cognitive, and other aspects of the animals' abilities after a stroke.

Exploration of The Interaction Between DAPK1 And Tau in Stroke

In view of the important role tau plays in neurological diseases and the interaction of tau with DAPK1 to regulate multiple pathological pathways, Ace Therapeutics offers comprehensive services to explore the specific mechanisms underlying the role of tau in stroke pathology.

• We provide comprehensive services to explore the potential serine and threonine phosphorylation sites of tau in embryonic development, neural deformation, and neuronal death through qualitative and quantitative whole proteome assays and qualitative and quantitative phosphorylated proteome assays for each phosphorylation site.
• We provide different methods for neuronal activity assays and identify neuronal differentiation by morphological and biological characterization in response to tau in stroke pathology.

Exploration of The Interaction Between DAPK1 And p53 in Stroke

Since the interaction of DAPK1 and p53 is considered as a signaling point for the convergence of necrotic and apoptotic pathways, Ace Therapeutics provides quality services to explore the interaction between DAPK1 and p53 on cell death in stroke.

• We provide complete identification services for the different modes of brain cell death, such as cell apoptosis, necrosis, pyroptosis, ferroptosis, and other forms during stroke pathology.
• We perform separate neuronal activity assays for p53 in different parts of the brain as well as in the nucleus and cytoplasm of cells to comprehensively assess the effect of the interaction between DAPK1 and p53 on neuronal activity.

For the interaction of DAPK1 with other targets such as NR2B, caytaxin, DANGER, and other targets, we also provide comprehensive exploration services. If you would like to learn more about our services, please feel free to contact us.

1. Wang, S., et al., Dapk1 signaling pathways in stroke: From mechanisms to therapies. Mol Neurobiol, 2017. 54(6): p. 4716-4722.