Exploration of the Role of Differential Targets in Stroke

It is an important research tool to explore the role played by differential targets in stroke pathology and the cascade of responses it involves. Studies on stroke pathogenesis can be more specific and the results can be more detailed by starting with differential targets. Therefore, Ace Therapeutics provides a quality service to comprehensively explore the role of differential targets in the pathological process of stroke. Our services target targets in the areas of nucleic acids and proteins. For different types of targets, we provide the most specialized and comprehensive services to accelerate your stroke research.

Exploration of the Role of Differential Targets of Excitotoxicity in Stroke

Excitotoxicity plays an important role in stroke, especially in ischemic stroke. The signaling cascade of excitotoxicity can occur rapidly after stroke onset and exacerbate the damage of stroke. Ace Therapeutics offers comprehensive exploration services for important targets in the excitotoxicity process in stroke.

• Glutamate plays an important role in excitotoxicity as an excitatory neurotransmitter, and its excessive release is a major element in initiating brain injury progression through activation of N-methyl-D-aspartate (NMDA), voltage-gated (L-type) and quisqualate (Q) postsynaptic receptor complexes.
• Excessive glutamate release leads to excessive activation of NMDA receptors (NMDAR) and causes Ca²⁺ overload, which in turn induces a series of pro-death signals.
• Postsynaptic density protein-95 (PSD-95) is an NMDAR receptor-associated protein that binds NMDAR and neuronal nitric oxide synthase at excitatory synapses and assembles them into a signaling complex.

Exploration of the Role of Differential Targets of Inflammation & Oxidative Stress Processes in Stroke

During stroke pathology, inflammatory and oxidative stress responses are important in the induction of neuronal death. Therefore, exploring the role played by differential targets during inflammatory and oxidative stress responses in stroke pathology is essential to understand the pathogenesis of stroke. Ace Therapeutics provides comprehensive services to explore the role played by targets in the inflammatory response and oxidative stress processes in the pathology of stroke.

• Tau has a variety of different activities with posttranslational modification and it regulates stroke progression through multiple pathways, including inflammatory responses and oxidative stress. We provide quality services to explore the specific roles played by different forms of tau in stroke.
• HSP70 modulates the stroke-induced inflammatory response by enhancing the immune response, in addition to its ability to regulate the stroke-induced cell death signaling pathway. We have provided different services for its specific mechanism of action.
• UCHL1 can modulate stroke pathological processes by regulating oxidative stress, neuroinflammation, and other processes. In addition, it prevents the accumulation of toxic proteins as an important component of the ubiquitin proteasome pathway and ensures the proper functioning of the body.

Exploration of the Role of Differential Targets of Other Processes in Stroke

Ace Therapeutics provides targeted services for regulating neural function, cell proliferation, cell differentiation, and other mechanisms of action.

• For neurological function in stroke, we provide different biological services for different mechanisms of action, such as nerve fiber growth, vascular repair, synaptic growth, and other aspects of function.
• For cellular life activity in stroke, we provide different services to address the needs of cell proliferation, cell differentiation, and other mechanisms of detection.
• For the regulation of nucleic acids in stroke, we offer comprehensive services with non-coding RNAs as the entry point.

If you would like to learn more about our services, please feel free to contact us.