Exploration of the Role of Gut Microbiota in Stroke

The onset of stroke affects the gut microbiota, while the gut microbiota also promotes the development of stroke. Although we have already known that the gut microbiota plays an important role in stroke, the exact mechanism of action needs to be studied in more depth. In response to this phenomenon, Ace Therapeutics offers a comprehensive service to explore in depth the role of the gut microbiota in the development of stroke.

Exploration of the Role of Microbial Signaling Molecules in Stroke

Microbial signaling molecules include bacterial structural components and metabolites of the intestinal microbiota, which can affect the intestinal ecology and intestinal barrier function, even can induce complications and promote the worsening of stroke. With this in mind, Ace Therapeutics offers a comprehensive service to explore the role of microbial signaling molecules in stroke.

• Through drug treatment and genetic manipulation, we have successfully developed different in vitro and in vivo models for studying the role of microbial signaling molecules in stroke.
• For bacterial structural components, such as lipopolysaccharide (LPS) and lipoteichoic acid, we provide different assays for the level of bacterial structural components, and content detection of relevant biomarkers, such as C-reactive protein, TLR4, TLR2, and LPS binding protein.
• For gut microbiota metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and other known signature metabolites, we have a gut microbiota targeted metabolomics analysis platform to provide high-throughput absolute quantitative assays of known metabolites. For unknown metabolites, we offer a gut microbiota untargeted metabolomics platform to analyze metabolic profiles, dynamic changes in metabolic levels, screening for differential metabolites, and other related services.

Exploration of the Role of Gut Dysbiosis in Stroke

Many clinical studies have verified that stroke patients often present with symptoms of gut dysbiosis. In view of this, Ace Therapeutics provides a different approach to investigating the altered gut microbiota in stroke model animals. We assessed the impact of stroke on the gut microbiota ecology at different levels.

• Conventional isolation and culture analysis techniques for gut microbiota
• Genetic assays for gut microbiota
• Mass spectrometry for gut microbiota

Exploration of the Role of Microbiota-Gut-Brain Axis in Stroke

Stroke attacks can lead to neuroinflammation and immune response. As a major organ of the immune response, the digestive tract regulates the pathological process of stroke through the microbiota-gut-brain axis. Therefore, Ace Therapeutics provides a comprehensive service to promote the understanding of the role of the microbiota-gut-brain axis in the stroke process.

We evaluate the effects of stroke-induced inflammation and immune response on the gut microbiota by measuring the number and distribution of cytokines, the number and distribution of immune cells, the levels of blood biomarkers, and the number and distribution of damage signals released by dying cells from the ischemic core and peri-infarct areas.

If you would like to learn more about our services, please feel free to contact us.

1. Pluta, R., et al., The role of gut microbiota in an ischemic stroke. Int J Mol Sci, 2021. 22(2).
2. Yamashiro, K., et al., Role of the gut microbiota in stroke pathogenesis and potential therapeutic implications. Ann Nutr Metab, 2021. 77 Suppl 2(Suppl 2): p. 36-44.