In Vivo Modeling of Hemorrhagic Stroke

in vivo Modeling of Hemorrhagic Stroke

Although hemorrhagic stroke accounts for a small percentage of stroke incidence, it has a high mortality rate and variable sequelae. Therefore, investigating the pathogenesis of hemorrhagic stroke is essential for understanding hemorrhagic stroke and even developing treatments for it. Animal models of hemorrhagic stroke are essential research tools. In view of this, Ace Neuroscience provides a wealth of hemorrhagic stroke models to facilitate the progress of hemorrhagic stroke research.

Autologous Blood Injection Model

The autologous blood injection model is an injection of blood from an animal collected from an easily accessible artery into a targeted brain region. The amount of blood injected and the rate of injection in this model can have different effects on the modeling results. Through continuous exploration, we have explored a perfect method to establish the autologous blood injection model, which can meet the needs of different studies.

Bacterial Collagenase Injection Model

In the bacterial collagenase injection model, intracerebral hemorrhage is simulated by injecting bacterial collagenase into the basal ganglia region. Depending on the specific requirements of the experiment, collagenase can be injected into most areas of the brain. We have mapped out the appropriate bacterial collagenase concentration, injection volume, and injection method to consistently establish the appropriate bacterial collagenase injection model.

Balloon Inflation Model

The balloon inflation model is a less common mechanical model of intracerebral hemorrhage that can be used to study the mass effect of hematoma and its effect on the clearance of ischemic brain injury. By effectively controlling the volume of the balloon and the time of inflation, we can steadily control the state of the balloon inflation model effect.

Endovascular Filament Model

There are two ways to implement the endovascular filament model, the main difference being whether or not to perform a craniotomy. We will customize the right animal model for you according to your experimental needs, or customize the model solution according to your requirements.

Blood Injection Model

The blood injection model simulates human subarachnoid hemorrhage by introducing autologous blood into the subarachnoid space. In building this model, fresh blood, blood products, and blood clots can be injected. The volume of injected blood, injection rate, and injection method are varied to simulate human subarachnoid hemorrhage under different pathological conditions.

No model can fully simulate the pathology of hemorrhagic stroke in humans, and in addition, many factors can influence the outcome of hemorrhagic stroke. Therefore, stably and scientifically established target hemorrhagic models are essential for the realism and objectivity of the study. Therefore, our aim is to provide stable and successful animal models of hemorrhagic stroke according to the needs of your experiment. In addition to the above models, we also provide other in vivo models of hemorrhagic strokes, such as prechiasmatic models and cisterna magna models. If you would like to learn more about our services, please feel free to contact us.

Reference
  1. Strbian, D., et al., Rodent models of hemorrhagic stroke. Curr Pharm Des, 2008. 14(4): p. 352-358.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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