Pharmacokinetic Testing

Pharmacokinetics quantitatively describes the dynamic changes of drugs in the body and studies the absorption, distribution, metabolism, and excretion processes of drugs entering the body through various routes. Pharmacokinetic studies further confirm the structure of metabolites, study the efficacy or toxicity of metabolites, and make the results available for the targeted synthesis, structural modification, and screening of new drugs. Given the importance of pharmacokinetics in preclinical drug studies, Ace Neuroscience offers comprehensive testing services to facilitate the study of pharmacokinetics in the development of new stroke-related drugs.

Pharmacokinetic Testing

Pharmacokinetic Testing Services

Ace Neuroscience provides comprehensive pharmacokinetic services for drug candidates from both in vitro and in vivo pharmacokinetic perspectives.

In Vitro Pharmacokinetic Testing

Pharmacokinetic studies in vitro allow the preliminary evaluation of the metabolism of drug candidates in cells and tissues and the types of metabolites, allowing the preliminary understanding of the distribution of the drug and the active ingredient.

  • We assess the physicochemical properties of drug candidates by measuring their water solubility, lipid solubility, permeability, plasma protein binding, stability, and other assays.
  • We examine drug candidate interactions with metabolic enzymes by providing studies including enzyme inhibition, enzyme induction, and enzyme phenotyping of P450 enzymes.
  • We elucidate drug candidate interactions with transporters at the gene and protein levels.
  • We examine the stability of drug candidates metabolized in vitro by different species of liver microsomes, hepatocytes, and others.
  • We identify in vitro metabolites by UV spectrophotometry, mass spectrometry, and other assays.

In Vivo Pharmacokinetic Testing

Pharmacokinetic studies in vivo provide a more comprehensive understanding of the drug candidate's fate and changes in vivo, leading to the interpretation of the drug candidate's efficacy and safety, and evaluation of the drug candidate's "drug-forming properties". We provide comprehensive in vivo pharmacokinetic studies to fully elucidate the in vivo pharmacokinetic profile of drug candidates, including absorption studies, hemodynamic studies, tissue distribution studies, metabolism studies, and excretion studies.

Central Nervous System Pharmacokinetic Testing Services

As a brain disease, the pharmacokinetic profile of stroke drugs in the central nervous system is crucial for drug development and research. In particular, the blood-brain screen hinders the entry of most drugs. Therefore, in addition to general pharmacokinetic testing services, Ace Neuroscience targets the stroke research process by testing the CNS pharmacokinetics of drug candidates through various test indicators, such as free drug concentration in the brain, brain-plasma free drug ratio, brain - plasma total drug ratio, free drug ratio fraction, blood-brain barrier permeability, and efflux ratio. Meanwhile, we provide physiologically-based pharmacokinetic models constructed according to the structural characteristics of brain tissue to provide targeted pharmacokinetic data in the brain. Our scientists will design the most appropriate physiologically - based pharmacokinetic models of brain tissue for your research purposes in the most scientifically and conveniently available form for your convenience.

Pharmacokinetic Testing

If you would like to learn more about our services, please feel free to contact us.

Reference
  1. Walker, D. K., The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. Br J Clin Pharmacol, 2004. 58(6): p. 601-608.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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