Quantitative Pharmacodynamic Analysis Services for Stroke

The quantitative analysis of pharmacodynamics includes five aspects: concentration-effect relationship analysis, time-effect relationship analysis, structure-activity relationship analysis, time-concentration relationship analysis, and drug-target relationship analysis. Through the quantitative analysis of pharmacodynamics, we can obtain various information about the pharmacodynamic effects of the drug candidates, such as how the effects are exerted, the intensity of the effects, whether the effects are sustained, what are the patterns of the effects with respect to time and dose, and other information. Ace Neuroscience offers comprehensive services for the quantitative analysis of the pharmacodynamics of drug candidates for stroke. Our professional services are designed solely to facilitate the development of stroke drugs.

Quantitative Pharmacodynamic Analysis Services for Stroke

Concentration-Effect Relationship Analysis Services

Based on our rich cell library and experimental animals, in the concentration-effect relationship analysis, Ace Neuroscience performs experiments on multiple specimens to draw concentration-effect curves and obtain rich concentration-effect relationship data.

Commonly used data include

  • Concentration for 50% of maximal effect (EC50) - The concentration that elicits 50% of the maximum effect
  • Median effective dose (ED50) - ED50 is the dose that elicits 50% of the maximal response strength in a quantitative response and 50% of the positive response in a qualitative response
  • Median lethal dose (LD50) - The minimum amount of bacteria or toxin required to kill half of an animal of given body weight or age by a specified route of infection within a specified time period
  • Median toxic dose (TD50) - The dose that causes 50% intoxication in an animal tested in a single toxicity test with prolonged and continuous exposure to a substance.

Time-Effect Relationship Analysis Services

After a drug enters the body, it roughly goes through the process of drug effect presentation, peak effect, effect disappearance, elimination from the body, and others. The change in drug effects over time is the time-effect relationship of the drug. By setting different time points for drug administration and testing the effects of drugs in different cells or animals, Ace Neuroscience provides comprehensive analysis services of the time-effect relationship.

The time-effect relationship can be divided into 3 phases. Our scientists will specify the appropriate experimental protocol for your stroke study.

  • Latent phase: from the beginning of drug administration to the appearance of the effect
  • Duration: from the appearance of the effect to its disappearance
  • Residual phase: from the disappearance of the effect to the complete elimination of the drug in the body

Structure-Activity Relationship Analysis Services

The study of structure-activity relationships can elucidate the structures in which chemical drug candidates exert their effects while contributing to the rapid discovery of additional potential drugs. Ace Neuroscience provides 2-dimensional quantitative conformational analysis services and 3-dimensional quantitative conformational analysis services to facilitate the progress of your stroke drug research with comprehensive, high quality, and professional services.

  • 2-dimensional quantitative conformational analysis services
    Select the appropriate data to be tested and create the database to be tested
    Select the appropriate molecular structure parameters and the activity parameters to be studied from the database
    Select a suitable method to model the quantitative relationship between structural and activity parameters
    Model testing and optimization
    Practical application to predict the activity of new compounds
  • 3-dimensional quantitative conformational analysis services
    The 3-dimensional quantitative conformational relationship analysis of drug candidates was performed by comparative molecular field analysis method and comparative molecular similarity method.

In addition, we offer services for time-concentration relationship and drug-target relationship analysis. We are constantly optimizing our technology only to better facilitate your research. If you would like to learn more about our services, please feel free to contact us.

Reference
  1. Currie, G. M., Pharmacology, part 1: Introduction to pharmacology and pharmacodynamics. J Nucl Med Technol, 2018. 46(2): p. 81-86.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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