Stroke Drug Development Targeting Tau

Current studies have demonstrated that tau is involved in regulating the pathology of stroke through multiple pathological pathways, such as oxidative stress, neuroinflammation, excitotoxicity, autophagy, and mitochondrial dysfunction. These findings suggest that modulation of tau is a potential therapeutic pathway for stroke. However, there are few studies on the development of stroke drugs targeting tau. Ace Neuroscience offers a range of services, from screening potential stroke drugs targeting tau and the pharmacological evaluation of drug candidates, to data analysis. Our goal is to facilitate the development of your stroke drug targeting tau.

High Throughput Screening of Tau Inhibitor

The current study found that stroke leads to elevated levels of total tau in human cerebrospinal fluid. And a combination of different studies found that inhibition of tau expression would in turn ameliorate stroke by modulating pathological pathways such as oxidative stress, excitotoxicity, angiogenesis, and mitochondrial dysfunction. Therefore, we first obtain tau inhibitors by high-throughput screening and then evaluate their pharmacological activity against stroke. In view of this, Ace Neuroscience has established a sophisticated screening service platform for tau inhibitors.

• We have an ultra-large small molecules library, including compound libraries, natural product libraries, and fragment libraries.
• We have established a high-throughput screening platform for tau that can screen tens of thousands of compounds at scale.
• We have established different in vitro and in vivo models of tau expression abnormalities by drug administration and genetic manipulation to validate the inhibitory effect of tau inhibitor candidates.

Preclinical Evaluation of Drug Candidates for the Treatment of Stroke

We have demonstrated the inhibitory effect of tau inhibitor candidates on tau. Immediately after, we offer various pharmacological activity evaluation services to test the therapeutic effect of candidate tau inhibitors on stroke.

• We have established different in vitro and in vivo stroke models to validate the therapeutic effect of tau inhibitors on stroke and to further explore the mechanism of tau action.
• We have established in vitro and in vivo models of oxidative stress, apoptosis, autophagy, excitotoxicity, inflammation, and mitochondrial dysfunction to explore the specific roles played by candidate inhibitors under these different pathological conditions.
• For tau, we provide detection and quantification of Tau aggregates in brain tissue to accurately assess the mechanism of tau action.
• For tau downstream genes or proteins, we provide different expression level assays and localization services to further explore the role of candidate inhibitors in stroke development.

Regarding other directions of targeting tau to develop stroke drugs, such as tau aggregation blockers, we also offer complete drug development services. If you would like to learn more about our services, please feel free to contact us.

1. Chen, X. Jiang, H., Tau as a potential therapeutic target for ischemic stroke. Aging (Albany NY), 2019. 11(24): p. 12827-12843.
2. Pluta, R., et al., Tau protein dysfunction after brain ischemia. J Alzheimers Dis, 2018. 66(2): p. 429-437.