Exploration of the Role of Guanosine in Stroke

The protective role of guanosine in the pathological process of ischemic stroke is gradually being revealed as research progresses, but this is only the tip of the iceberg. Ace Therapeutics provides comprehensive exploration services of the role of guanosine in stroke pathology. We provide a comprehensive service for its anti-inflammatory, anti-apoptotic, antioxidant, excitotoxic response inhibition, and other protective effects in ischemic stroke. In addition, current studies on guanosine in stroke are mainly focused on ischemic stroke, while studies on hemorrhagic stroke are rare. Therefore, we have expanded our research to further explore the potential role of guanosine in hemorrhagic stroke. Our comprehensive and high-quality service is only to facilitate the smooth development of your study.

Exploration of Neurotrophic Effects of Guanosine on Stroke

Given that guanosine is involved in stroke pathology through its role in mediating neurotrophy in the central nervous system, Ace Therapeutics offers high-quality and comprehensive services to explore its specific mechanisms of action. We offer dedicated services to explore the potential role of guanosine in neurogenesis, neuritogenesis, cell differentiation, and other pathways.

• We have a rich brain cell bank that can be used to validate the neurotrophic effects of guanosine in different brain cells.
• We provide different cell proliferation and differentiation assays for brain cells to comprehensively test the proliferative and differentiation activities of guanosine on brain cells.
• We provide different methods to detect the effect of guanosine on the apoptosis of brain cells caused by stroke.
• We have optimized the brain cell culture model to more visually characterize and quantify the neuronal growth process.
• We offer protocols and techniques for the detection of various neurotrophic factors.

Exploration of Neuroprotection Effects of Guanosine on Stroke

Ace Therapeutics has provided quality scientific services in order to explore the neuroprotective role played by guanosine in stroke pathology. Based on the existing studies, we summarize the potential neuroprotective effects and design targeted protocols for mechanism exploration to meet the needs of different studies.

• For the activity of guanosine to inhibit excitotoxic processes by stimulating glutamate uptake by brain cells, we have developed different stroke models to investigate the effect of guanosine on glutamate concentration in excitotoxicity, and provide different assays to detect changes in biomarker levels.
• To address the anti-apoptotic, antioxidant, anti-inflammatory, and other protective properties of guanosine through mediating the G protein-coupled receptor, phosphatidylinositol-3 kinase (PI3K)/Akt, mitogen-activated protein kinases (MAPKs) and other signaling pathways, we perform high-throughput screening and more in-depth studies on the relevant signaling pathway changes by modulating the expression of guanosine in the models.

In addition, we provide corresponding exploration services for other activities exerted by guanosine in stroke pathological processes, such as the relationship between guanosine and ischemia-induced endothelial activation, the relationship between guanosine and the permeability and integrity of the blood brain barrier, the relationship between guanosine and immune response and inter-immune cell, the effect of guanosine acid on brain cell death and other pathological processes. If you would like to learn more about our services, please feel free to contact us.

1. Kesavardhana, S., et al., Caspases in cell death, inflammation, and pyroptosis. Annu Rev Immunol, 2020. 38: p. 567-595.
2. Gou, X., et al., Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies. J Physiol Biochem, 2021. 77(4): p. 511-529.